| A-ploeg dames – eerste nationale | ||||
| 28/08/2021 | 15:00 | Voetbalclub Moldavo | KV Mechelen | 0 – 5 |
| 04/09/2021 | 17:00 | KV Mechelen | KRC Genk B | 7 – 0 |
| 11/09/2021 | 14:30 | KSK Voorwaarts Zwevezele | KV Mechelen | 1 – 2 |
| 18/09/2021 | 17:00 | KV Mechelen | R. Standard de Liège B | 2 – 0 |
| 02/10/2021 | 18:30 | RSC Anderlecht B | KV Mechelen | 1 – 3 |
| 09/10/2021 | 17:00 | KV Mechelen | K. Kontich FC | 3 – 2 |
| 16/10/2021 | 17:30 | RFC de Liège | KV Mechelen | 1 – 9 |
| 23/10/2021 | 17:00 | KV Mechelen | Oud-Heverlee Leuven B | 0 – 0 |
| 06/11/2021 | 14:30 | K. Wuustwezel FC | KV Mechelen | 0 – 6 |
| 20/11/2021 | 16:00 | Famkes WDM | KV Mechelen | 1 – 2 |
| 04/12/2021 | 14:00 | KVK Tienen | KV Mechelen | 1 – 4 |
| 11/12/2021 | 17:00 | ASE de Chastre | KV Mechelen | 0 – 6 |
| 18/12/2021 | 17:00 | KV Mechelen | KAA Gent B | 2 – 3 |
| 29/01/2022 | 17:00 | KV Mechelen | KSK Voorwaarts Zwevezele | 2 – 2 |
| 05/02/2022 | 17:00 | R. Standard de Liège B | KV Mechelen | 2 – 2 |
| 12/02/2022 | 17:00 | KV Mechelen | RSC Anderlecht B | 2 – 0 |
| 19/02/2022 | 15:30 | K. Kontich FC | KV Mechelen | 0 – 2 |
| 26/02/2022 | 17:00 | KV Mechelen | RFC de Liège | 6 – 0 |
| 02/03/2022 | 20:00 | KV Mechelen | Renaissance Mons 44 | 1 – 0 |
| 12/03/2022 | 17:00 | KV Mechelen | K. Wuustwezel FC | 2 – 3 |
| 19/03/2022 | 17:00 | Renaissance Mons 44 | KV Mechelen | 1 – 2 |
| 26/03/2022 | 17:00 | KV Mechelen | Famkes WDM | 6 – 0 |
| 02/04/2022 | 17:00 | KV Mechelen | Voetbalclub Moldavo | 4 – 2 |
| 16/04/2022 | 17:00 | KV Mechelen | KVK Tienen | 4 – 3 |
| 20/04/2022 | 20:00 | KRC Genk B | KV Mechelen | 2 – 1 |
| 24/04/2022 | 15:00 | Oud-Heverlee Leuven B | KV Mechelen | 0 – 5 ff |
| 30/04/2022 | 16:00 | KV Mechelen | ASE de Chastre | 9 – 1 |
| 07/05/2022 | 16:00 | KAA Gent B | KV Mechelen | 5 – 0 |
wedstrijdfiches + statistieken A-ploeg dames
| klassement dames eerste nationale | G | W | D | V | G+ | G- | S | P | |
| 1 | KAA Gent B | 28 | 24 | 0 | 4 | 108 | 31 | 77 | 72 |
| 2 | KV Mechelen | 28 | 21 | 3 | 4 | 99 | 31 | 68 | 66 |
| 3 | K. Kontich FC | 28 | 18 | 2 | 8 | 98 | 41 | 57 | 56 |
| 4 | KSK Voorwaarts Zwevezele | 28 | 18 | 2 | 8 | 84 | 55 | 29 | 56 |
| 5 | Oud-Heverlee Leuven B | 28 | 14 | 6 | 8 | 94 | 58 | 36 | 48 |
| 6 | R. Standard de Liège B | 28 | 12 | 6 | 10 | 51 | 52 | -1 | 42 |
| 7 | KRC Genk B | 28 | 11 | 8 | 9 | 55 | 62 | -7 | 41 |
| 8 | K. Wuustwezel FC | 28 | 12 | 2 | 14 | 64 | 86 | -22 | 38 |
| 9 | RSC Anderlecht B | 28 | 10 | 8 | 10 | 61 | 60 | 1 | 38 |
| 10 | Voetbalclub Moldova | 28 | 10 | 5 | 13 | 62 | 67 | -5 | 35 |
| 11 | Famkes Westhoek Diksmuide Merkem | 28 | 8 | 4 | 16 | 46 | 67 | -21 | 28 |
| 12 | RFC de Liège | 28 | 7 | 7 | 14 | 28 | 58 | -30 | 28 |
| 13 | Renaisscance AEC Mons | 28 | 6 | 5 | 17 | 42 | 85 | -43 | 23 |
| 14 | KVK Tienen | 28 | 4 | 3 | 21 | 30 | 88 | -58 | 15 |
| 15 | ASE de Chastre | 28 | 2 | 5 | 21 | 34 | 115 | -81 | 11 |
Omdat de B-ploeg van KAA Gent niet kan promoveren gaat de promotie naar KV Mechelen
dat voor het eerst in z’n bestaan in de hoogste afdeling, de Scooore Super League, terecht komt!
| B-ploeg dames – tweede nationale B | ||||
| 28/08/2021 | 17:00 | KV Mechelen B | KVC Westerlo | 2 – 1 |
| 04/09/2021 | 15:00 | Wallonia Club Sibret A | KV Mechelen B | 2 – 3 |
| 11/09/2021 | 14:15 | ASE de Chastre B | KV Mechelen B | 1 – 3 |
| 02/10/2021 | 17:00 | KV Mechelen B | KVV Vosselaar | 1 – 3 |
| 09/10/2021 | 15:00 | FC Irlande Auderghem | KV Mechelen B | 1 – 3 |
| 16/10/2021 | 17:00 | KV Mechelen B | R. Aywaille FC | 2 – 0 |
| 23/10/2021 | 15:00 | KSK Heist | KV Mechelen B | 2 – 1 |
| 06/11/2021 | 17:00 | KV Mechelen B | FC Alken | 4 – 0 |
| 13/11/2021 | 16:00 | FC Fémina WS Woluwe B | KV Mechelen B | 1 – 2 |
| 20/11/2021 | 17:00 | KV Mechelen B | R. Standard de Liège C | 2 – 1 |
| 27/11/2021 | 15:30 | R. Olympic Club Charleroi | KV Mechelen B | alg. ff |
| 04/12/2021 | 17:00 | KV Mechelen B | VVC Brasschaat | 1 – 0 |
| 11/12/2021 | 17:00 | RUS Loyers | KV Mechelen B | 3 – 4 |
| 29/01/2022 | 17:00 | KV Mechelen B | ASE de Chastre B | 4 – 1 |
| 05/02/2022 | 15:00 | KVV Vosselaar | KV Mechelen B | 3 – 0 |
| 12/02/2022 | 14:15 | KVC Westerlo | KV Mechelen B | 3 – 0 |
| 19/02/2022 | 17:00 | KV Mechelen B | FC Irlande Auderghem | 5 – 0 |
| 26/02/2022 | 14:30 | R. Aywaille FC | KV Mechelen B | 0 – 4 |
| 05/03/2022 | 17:00 | KV Mechelen B | KSK Heist | 6 – 3 |
| 12/03/2022 | 17:00 | KV Mechelen B | Wallonia Club Sibret | 4 – 1 |
| 19/03/2022 | 16:00 | FC Alken | KV Mechelen B | 6 – 2 |
| 26/03/2022 | 17:00 | KV Mechelen B | FC Fémina WS Woluwe B | 3 – 1 |
| 16/04/2022 | 17:00 | R. Standard de Liège C | KV Mechelen B | 2 – 1 |
| 23/04/2022 | 17:00 | KV Mechelen B | R. Olympic Club Charleroi | alg. ff |
| 30/04/2022 | 14:00 | VVC Brasschaat | KV Mechelen B | 4 – 1 |
| 07/05/2022 | 14:00 | KV Mechelen B | RUS Loyers | 5 – 0 ff |
| klassement dames tweede nationale B | G | W | D | V | G+ | G- | S | P | |
| 1 | KVC Westerlo | 24 | 22 | 0 | 2 | 126 | 21 | 105 | 66 |
| 2 | KVV Vosselaar | 24 | 22 | 0 | 2 | 104 | 24 | 80 | 66 |
| 3 | KV Mechelen B | 24 | 17 | 0 | 7 | 63 | 39 | 24 | 51 |
| 4 | FC Alken | 24 | 13 | 3 | 8 | 84 | 59 | 25 | 42 |
| 5 | VVC Brasschaat | 24 | 13 | 2 | 9 | 81 | 48 | 33 | 41 |
| 6 | FC Fémina White Star Woluwe B | 24 | 13 | 2 | 9 | 56 | 45 | 11 | 41 |
| 7 | R. Standard de Liège C | 24 | 12 | 2 | 10 | 58 | 39 | 19 | 38 |
| 8 | RUS Loyer | 24 | 10 | 2 | 12 | 72 | 79 | -7 | 32 |
| 9 | KSK Heist | 24 | 7 | 0 | 17 | 47 | 99 | -52 | 21 |
| 10 | R. Wallonia Club Sibret | 24 | 5 | 6 | 13 | 40 | 64 | -24 | 21 |
| 11 | FC Irlande Auderghem | 24 | 5 | 1 | 18 | 34 | 86 | -52 | 16 |
| 12 | R. Aywaile FC | 24 | 4 | 1 | 19 | 28 | 103 | -75 | 13 |
| 13 | ASE de Chastre B | 24 | 3 | 1 | 20 | 27 | 114 | -87 | 10 |
| 14 | R. Olympic Club Charleroi | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| beker van België A-ploeg | |||||
| 21/08/2021 | 17:00 | vierde ronde | KV Mechelen A | K. Olsa Brakel | 17 – 0 |
| 25/09/2021 | 14:30 | 1/16de finale | KSK Voorwaarts Zwevezele | KV Mechelen A | 2 – 3 |
| 30/10/2021 | 17:00 | 1/8ste finale | KV Mechelen A | R. Standard de Liège | 0 – 5 |
| beker van België B-ploeg | |||||
| 14/08/2021 | 16:00 | derde ronde | KV Mechelen B | US Auvelais | 16 – 0 |
| 21/08/2021 | 17:00 | vierde ronde | KV Mechelen B | Famkes Westhoek DM | 1 – 3 |