| 06/09/1970 | AS Eupen – KV Mechelen | 1 – 2 | eerste zege |
| 13/09/1970 | KV Mechelen – AS Oostende | 1 – 1 | |
| 20/09/1970 | K. Beeringen FC – KV Mechelen | 1 – 1 | |
| 27/09/1970 | KV Mechelen – ROC Charleroi | 5 – 2 | |
| 04/10/1970 | KSV Sottegem – KV Mechelen | 1 – 6 | grootste zege |
| 11/10/1970 | KV Mechelen – KRC Mechelen | 2 – 0 | |
| 18/10/1970 | KV Mechelen – KSV Waterschei THOR Genk | 2 – 0 | |
| 25/10/1970 | RCS Verviétois – KV Mechelen | 0 – 0 | |
| 01/11/1970 | KV Mechelen – KFC Turnhout | 3 – 0 | |
| 15/11/1970 | K. Berchem Sport – KV Mechelen | 2 – 0 | eerste en grootste verlies |
| 22/11/1970 | KV Mechelen – RAA Louvièroise | 0 – 0 | |
| 29/11/1970 | R. Tilleur FC – KV Mechelen | 2 – 4 | |
| 06/12/1970 | K. Sint-Niklaasse SK – KV Mechelen | 0 – 0 | |
| 13/12/1970 | KV Mechelen – R. Daring Club de Molenbeek | 1 – 0 | |
| 20/12/1970 | KSV Cercle Brugge – KV Mechelen | 2 – 0 | grootste verlies |
| 10/01/1971 | KV Mechelen – AS Eupen | 0 – 0 | |
| 17/01/1971 | AS Oostende – KV Mechelen | 1 – 4 | |
| 24/01/1971 | KV Mechelen – K. Beeringen FC | 1 – 0 | |
| 07/02/1971 | ROC Charleroi – KV Mechelen | 1 – 2 | |
| 21/02/1971 | KV Mechelen – KSV Sottegem | 2 – 1 | |
| 28/02/1971 | KRC Mechelen – KV Mechelen | 3 – 1 | grootste verlies |
| 14/03/1971 | KV Mechelen – RCS Verviétois | 3 – 0 | |
| 21/03/1971 | KFC Turnhout – KV Mechelen | 2 – 2 | |
| 28/03/1971 | KV Mechelen – K. Berchem Sport | 1 – 0 | |
| 04/04/1971 | RAA Louvièroise – KV Mechelen | 0 – 2 | |
| 11/04/1971 | KSV Waterschei THOR Genk – KV Mechelen | 0 – 1 | |
| 18/04/1971 | KV Mechelen – R. Tilleur FC | 5 – 0 | grootste zege |
| 25/04/1971 | KV Mechelen – K. Sint-Niklaasse SK | 2 – 2 | |
| 02/05/1971 | R. Daring Club de Molenbeek – KV Mechelen | 1 – 2 | |
| 09/05/1971 | KV Mechelen – KSV Cercle Brugge | 3 – 0 |
| eindklassement tweede nationale | aantal | winst | gelijk | verlies | goals+ | goals- | ptn | |
| 1 | KONINKLIJKE SPORTVERENIGING CERCLE BRUGGE | 30 | 20 | 6 | 4 | 50 | 20 | 46 |
| 2 | KONINKLIJKE VOETBALKLUB MECHELEN | 30 | 19 | 8 | 3 | 58 | 23 | 46 |
| 3 | Koninklijke Racing Club Mechelen | 30 | 18 | 7 | 5 | 54 | 29 | 43 |
| 4 | Koninklijke Beeringen Football Club | 30 | 17 | 9 | 4 | 50 | 18 | 43 |
| 5 | Royale Association Athlétique Louvièroise | 30 | 13 | 7 | 10 | 40 | 39 | 33 |
| 6 | Koninklijke Sint-Niklaasse Sportkring | 30 | 9 | 13 | 8 | 32 | 26 | 31 |
| 7 | Koninklijke Sportvereniging Waterschei THOR Genk | 30 | 12 | 6 | 12 | 31 | 30 | 30 |
| 8 | Koninklijk Berchem Sport | 30 | 11 | 7 | 12 | 29 | 31 | 29 |
| 9 | Koninklijke Football Club Turnhout | 30 | 11 | 6 | 13 | 38 | 40 | 28 |
| 10 | Royal Daring Club de Molenbeek | 30 | 9 | 10 | 11 | 35 | 41 | 28 |
| 11 | Royal Tilleur Football Club | 30 | 11 | 2 | 17 | 41 | 46 | 24 |
| 12 | Alliance Sportive Eupen | 30 | 8 | 7 | 15 | 21 | 35 | 23 |
| 13 | Royal Club Sportif Verviétois | 30 | 7 | 9 | 14 | 22 | 43 | 23 |
| 14 | Royal Olympic Club Charleroi | 30 | 7 | 8 | 15 | 31 | 49 | 22 |
| 15 | Atletische Sportvereniging Oostende | 30 | 5 | 7 | 18 | 26 | 54 | 17 |
| 16 | Koninklijke Sportvereniging Sottegem | 30 | 6 | 2 | 22 | 26 | 60 | 14 |