| 29-07-2016 | KV Mechelen | Club Brugge KV | 0-2 | eerste nederlaag |
| 06-08-2016 | KAS Eupen | KV Mechelen | 0-2 | eerste zege |
| 13-08-2016 | KV Mechelen | KV Kortrijk | 0-0 | |
| 20-08-2016 | KV Red Star Waasland-SKB | KV Mechelen | 2-2 | |
| 27-08-2016 | KVC Westerlo | KV Mechelen | 1-2 | |
| 10-09-2016 | KV Mechelen | K. Sint-Truidense VV | 2-0 | |
| 16-09-2016 | Sporting du Pays de Charleroi | KV Mechelen | 0-0 | |
| 24-09-2016 | KV Mechelen | SV Zulte-Waregem | 2-3 | |
| 02-10-2016 | KRC Genk | KV Mechelen | 2-1 | |
| 16-10-2016 | KV Mechelen | KV Oostende | 2-3 | |
| 22-10-2016 | KV Mechelen | Excel Mouscron | 2-0 | |
| 26-10-2016 | RSC Anderlecht | KV Mechelen | 2-0 | |
| 30-10-2016 | KV Mechelen | KAA Gent | 2-0 | |
| 05-11-2016 | KSC Lokeren Oost-Vlaanderen | KV Mechelen | 0-0 | |
| 20-11-2016 | KV Mechelen | R. Standard de Liège | 2-1 | |
| 25-11-2016 | Club Brugge KV | KV Mechelen | 6-1 | grootste nederlaag |
| 02-12-2016 | KV Mechelen | KAS Eupen | 1-0 | |
| 10-12-2016 | Excel Mouscron | KV Mechelen | 1-4 | grootste zege |
| 17-12-2016 | KV Mechelen | KV Red Star Waasland-SKB | 2-0 | |
| 20-12-2016 | KV Mechelen | Sporting du Pays de Charleroi | 1-0 | |
| 26-12-2016 | SV Zulte-Waregem | KV Mechelen | 0-0 | |
| 22-01-2017 | KV Mechelen | KVC Westerlo | 1-2 | |
| 25-01-2017 | K. Sint-Truidense VV | KV Mechelen | 2-1 | |
| 28-01-2017 | KV Mechelen | KRC Genk | 1-0 | |
| 04-02-2017 | KV Oostende | KV Mechelen | 2-0 | |
| 11-02-2017 | KV Kortrijk | KV Mechelen | 0-2 | |
| 18-02-2017 | KV Mechelen | KSC Lokeren Oost-Vlaanderen | 3-0 | grootste zege |
| 26-02-2017 | R. Standard de Liège | KV Mechelen | 2-2 | |
| 04-03-2017 | KV Mechelen | RSC Anderlecht | 3-2 | |
| 12-03-2017 | KAA Gent | KV Mechelen | 3-0 |
| eindklassement reguliere competitie | gesp. | winst | gelijk | verlies | goals+ | goals- | saldo | punten | |
| 1 | RSC Anderlecht | 30 | 18 | 7 | 5 | 67 | 30 | 37 | 61 |
| 2 | Club Brugge KV | 30 | 18 | 5 | 7 | 56 | 24 | 32 | 59 |
| 3 | SV Zulte-Waregem | 30 | 15 | 9 | 6 | 49 | 38 | 11 | 54 |
| 4 | KAA Gent | 30 | 14 | 8 | 8 | 45 | 29 | 16 | 50 |
| 5 | KV Oostende | 30 | 14 | 8 | 8 | 52 | 37 | 15 | 50 |
| 6 | Sporting du Pays de Charleroi | 30 | 13 | 10 | 7 | 34 | 29 | 5 | 49 |
| 7 | KV Mechelen | 30 | 14 | 6 | 10 | 41 | 36 | 5 | 48 |
| 8 | KRC Genk | 30 | 14 | 6 | 10 | 40 | 35 | 5 | 48 |
| 9 | R. Standard de Liège | 30 | 10 | 12 | 8 | 47 | 38 | 9 | 39 |
| 10 | KV Kortrijk | 30 | 8 | 7 | 15 | 38 | 55 | -17 | 31 |
| 11 | KSC Lokeren Oost-Vlaanderen | 30 | 7 | 10 | 13 | 24 | 34 | -10 | 31 |
| 12 | K. Sint-Truidense VV | 30 | 8 | 6 | 16 | 35 | 48 | -13 | 30 |
| 13 | KAS Eupen | 30 | 8 | 6 | 16 | 40 | 64 | -24 | 30 |
| 14 | KV Red Star Waasland-SK Beveren | 30 | 7 | 9 | 14 | 28 | 43 | -15 | 30 |
| 15 | Excel Mouscron | 30 | 7 | 3 | 20 | 29 | 53 | -24 | 24 |
| 16 | KVC Westerlo | 30 | 5 | 8 | 17 | 33 | 65 | -32 | 23 |