| 24/07/2022 | KV Mechelen | R. Antwerp FC | 0 – 2 | eerste nederlaag |
| 30/07/2022 | KV Oostende | KV Mechelen | 2 – 1 | |
| 06/08/2022 | KV Mechelen | R. Union Saint-Gilloise | 3 – 0 | eerste overwinning |
| 13/08/2022 | Cercle Brugge KSV | KV Mechelen | 0 – 0 | |
| 21/08/2022 | KV Mechelen | KVC Westerlo | 5 – 4 | |
| 27/08/2022 | K. Sint-Truidense VV | KV Mechelen | 3 – 1 | |
| 03/09/2022 | KV Mechelen | FC Seraing | 2 – 3 | |
| 10/09/2022 | KV Kortrijk | KV Mechelen | 1 – 4 | grootste overwinning |
| 17/09/2022 | KV Mechelen | Oud-Heverlee Leuven | 0 – 0 | |
| 01/10/2022 | Club Brugge KV | KV Mechelen | 3 – 0 | |
| 09/10/2022 | KV Mechelen | RSC Anderlecht | 1 – 3 | |
| 16/10/2022 | KAA Gent | KV Mechelen | 3 – 0 | |
| 19/10/2022 | KV Mechelen | R. Standard de Liège | 2 – 0 | |
| 22/10/2022 | KV Mechelen | KAS Eupen | 2 – 1 | |
| 28/10/2022 | KRC Genk | KV Mechelen | 3 – 1 | |
| 05/11/2022 | KV Mechelen | SV Zulte- Waregem | 2 – 2 | |
| 12/11/2022 | Sporting du Pays de Charleroi | KV Mechelen | gestopt | na 68′ bij 1-0 (later 0-5 ff) |
| 23/12/2022 | KV Mechelen | Cercle Brugge KSV | 1 – 1 | |
| 08/01/2023 | SV Zulte-Waregem | KV Mechelen | 2 – 0 | |
| 14/01/2023 | KV Mechelen | KV Oostende | 2 – 1 | |
| 17/01/2023 | R. Standard de Liège | KV Mechelen | 2 – 0 | |
| 21/01/2023 | KV Mechelen | KV Kortrijk | 3 – 2 | |
| 28/01/2023 | KVC Westerlo | KV Mechelen | 2 – 0 | |
| 05/02/2023 | KV Mechelen | Sporting du Pays de Charleroi | 2 – 2 | |
| 10/02/2023 | KAS Eupen | KV Mechelen | 2 – 1 | |
| 17/02/2023 | KV Mechelen | KRC Genk | 2 – 2 | |
| 25/02/2023 | FC Seraing | KV Mechelen | 0 – 2 | |
| 05/03/2023 | R. Antwerp FC | KV Mechelen | 5 – 0 | grootste nederlaag |
| 11/03/2023 | KV Mechelen | K. Sint-Truidense VV | 1 – 0 | |
| 19/03/2023 | R. Union Saint-Gilloise | KV Mechelen | 2 – 1 | |
| 02/04/2023 | KV Mechelen | Club Brugge KV | 0 – 3 | |
| 08/04/2023 | Oud-Heverlee Leuven | KV Mechelen | 4 – 1 | |
| 16/04/2023 | KV Mechelen | KAA Gent | 1 – 1 | |
| 23/04/2023 | RSC Anderlecht | KV Mechelen | 2 – 3 |
| eindklassement reguliere competitie 2022-2023 | gesp. | winst | gelijk | verlies | goals+ | goals- | saldo | punten | |
| 1 | KRC Genk | 34 | 23 | 6 | 5 | 78 | 37 | 41 | 75 |
| 2 | R. Union Saint-Gilloise | 34 | 23 | 6 | 5 | 70 | 41 | 29 | 75 |
| 3 | R. Antwerp FC | 34 | 22 | 6 | 6 | 59 | 26 | 33 | 72 |
| 4 | Club Brugge KV | 34 | 16 | 11 | 7 | 61 | 36 | 25 | 59 |
| 5 | KAA Gent | 34 | 16 | 8 | 10 | 64 | 38 | 26 | 56 |
| 6 | R. Standard de Liège | 34 | 16 | 7 | 11 | 58 | 45 | 13 | 55 |
| 7 | KVC Westerlo | 34 | 14 | 9 | 11 | 61 | 53 | 8 | 51 |
| 8 | Cercle Brugge KSV | 34 | 13 | 11 | 10 | 50 | 46 | 4 | 50 |
| 9 | Sp. du Pays de Charleroi | 34 | 14 | 6 | 14 | 45 | 52 | -7 | 48 |
| 10 | Oud-Heverlee Leuven | 34 | 13 | 9 | 12 | 56 | 48 | 8 | 48 |
| 11 | RSC Anderlecht | 34 | 13 | 7 | 14 | 49 | 46 | 3 | 46 |
| 12 | K. Sint-Truidense VV | 34 | 11 | 9 | 14 | 37 | 40 | -3 | 42 |
| 13 | KV Mechelen | 34 | 11 | 7 | 16 | 49 | 63 | -14 | 40 |
| 14 | KV Kortrijk | 34 | 8 | 7 | 19 | 37 | 61 | -24 | 31 |
| 15 | KAS Eupen | 34 | 7 | 7 | 20 | 40 | 75 | -35 | 28 |
| 16 | KV Oostende | 34 | 7 | 6 | 21 | 37 | 76 | -39 | 27 |
| 17 | SV Zulte-Waregem | 34 | 6 | 9 | 19 | 50 | 78 | -28 | 27 |
| 18 | FC Seraing | 34 | 5 | 5 | 24 | 28 | 68 | -40 | 20 |